Trial Reviews

Review of the literature on recently published trials and how they can integrate into your practice.

CABG vs PCI in 2025: The Era of Equipoise

Leave a Comment / Trial Reviews /

Why This Debate Still Matters For decades, CABG and PCI have been cast as rivals—durability versus convenience. CABG promised long-term completeness of revascularization; PCI offered speed, recovery, and adaptability. With modern technology, that dichotomy is fading. The 5-year results of FAME 3, along with 10-year pooled data from SYNTAX and PRECOMBAT, show that physiology-guided, imaging-optimized […]

CABG vs PCI in 2025: The Era of Equipoise Read More »

HI-PRO Trial: Rethinking Anticoagulation After “Provoked” DVT

Leave a Comment / Trial Reviews /

Why this study matters For decades, we’ve used a neat binary: provoked = 3 months of anticoagulation, unprovoked = indefinite therapy. Easy enough to remember. The HI-PRO trial, presented at ESC 2025, asked whether the “3 months and done” rule holds up in patients who had a transient provoking factor and lingering, chronic risk features.

HI-PRO Trial: Rethinking Anticoagulation After “Provoked” DVT Read More »

Colchicine in Coronary Disease: Where We Stand Now

Leave a Comment / Trial Reviews /

Why colchicine, and why now? We’ve chased the inflammatory axis of atherosclerosis for decades. An age old drug (colchicine) has emerged as a pragmatic anti-inflammatory add-on for secondary prevention in chronic coronary disease (CCD). Prior trials highlight both promise and caveats: benefits on composites largely driven by fewer urgent revascularizations (and stroke in COLCOT)(1–3). What

Colchicine in Coronary Disease: Where We Stand Now Read More »

DAPT After CABG: Lessons From TACSI and TOP-CABG

Leave a Comment / Trial Reviews /

Aspirin after CABG has never been controversial. The controversy has always been: should we add a P2Y12 inhibitor, creating dual antiplatelet therapy (DAPT), to keep grafts open and prevent ischemic events? Part of the reason this debate matters is sobering. Despite our best surgical techniques, vein graft attrition is common. An article from Circulation in

DAPT After CABG: Lessons From TACSI and TOP-CABG Read More »

Subscribe
Subscribe